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Ibrutinib CAS 936563-96-1
Ibrutinib is a targeted therapy that irreversibly inhibits Bruton’s tyrosine kinase (BTK), blocking B-cell signaling to suppress cancer cell growth and survival.
Ibrutinib CAS 936563-96-1
- CAS: 936563-96-1
- Molecular Formula: C25H24N6O2
- Molecular Weight: 440.5
- EINECS: 805-642-2
- Synonyms: According to Lu imatinib; 2-Propen-1-one, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-; PCI-32765 (Ibrutinib); IBRUTINIB;1-[(3R)-3-[4-AMino-3-(4-phenoxyphenyl) pyrazolo [3, 4-d]pyriMidin-1-yl] piperidin-1-yl] prop-2-en-1-one; 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one Ibrutinib (PCI32765);PCI-32765 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one.
What is Ibrutinib CAS 936563-96-1?
Ibrutinib CAS 936563-96-1 represents a major advancement in targeted cancer therapy. It selectively inhibits BTK, thereby blocking signaling pathways essential for the proliferation and survival of malignant B cells. This mechanism provides a more effective and less toxic alternative to traditional chemotherapy.
Developed originally for hematological cancers, Ibrutinib has become an important therapeutic agent for chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenström’s macroglobulinemia (WM). Its high specificity and oral availability have made it one of the most successful targeted drugs in oncology.
Specifications
| Property | Value |
|---|---|
| Melting Point | 153-158°C |
| Boiling Point | 715.0±60.0 °C(Predicted)/td> |
| Density | 1.34 |
| Color | White to Off-White |
| Form | Solid |
| Stability | Stable for 1 year from the date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Solubility | Soluble in DMSO ( up to at least 25 mg/ml) |
| InChIKey | XYFPWWZEPKGCCK-GOSISDBHSA-N |
| SMILES | C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C |
| storage temp. | -20°C |
Features
- Targeted Mechanism: Selectively inhibits Bruton’s tyrosine kinase, minimizing damage to healthy cells.
- High Oral Bioavailability: Convenient once-daily oral dosing.
- Broad Therapeutic Spectrum: Effective across multiple B-cell malignancies.
- Clinically Proven Efficacy: Demonstrated significant survival benefits in hematologic cancer patients.
- Well-Studied Safety Profile: Extensive clinical data supporting long-term use and management of side effects.
Applications
- Chronic Lymphocytic Leukemia (CLL): Used as a first-line or relapsed therapy for CLL and small lymphocytic lymphoma (SLL).
- Mantle Cell Lymphoma (MCL): Approved for patients with relapsed or refractory MCL.
- Waldenström’s Macroglobulinemia (WM): Effective in treating this rare form of non-Hodgkin lymphoma.
- Chronic Graft-Versus-Host Disease (cGVHD): Used for patients who have not responded to standard corticosteroid therapy.
- Research Use: Employed in studies exploring BTK inhibition mechanisms and potential applications in autoimmune disorders.
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