4-Bromophenylhydrazine hydrochloride CAS 622-88-8

What is 4-Bromophenylhydrazine hydrochloride CAS 622-88-8?

4-Bromophenylhydrazine hydrochloride CAS 622-88-8 serves as a key building block in organic synthesis, especially for constructing indole derivatives and other nitrogen-containing heterocycles through reactions like the Fischer indole synthesis and related processes.

Specifications

Features

• High Reactivity: The active hydrazine core enables highly efficient condensation, hydrazone formation, and cyclization reactions.
• Bromo Functionality: The para-substituted bromine atom acts as a strategic functional handle for subsequent transition-metal catalyzed cross-coupling pathways (e.g., Suzuki, Heck, Buchwald-Hartwig) or nucleophilic substitutions.
• Hydrochloride Salt Form: Converting the native aromatic amine to its hydrochloride salt significantly enhances long-term crystalline stability, limits atmospheric oxidation, and simplifies safe industrial handling.
• Versatile Intermediate: Adapts seamlessly to diverse multi-step synthetic sequences spanning industrial bulk manufacturing and early-stage chemical design.

Applications

• Heterocycle Synthesis: Heavily utilized as an essential precursor in classic Fischer Indole Synthesis pathways to form multi-substituted bromoindoles, indoline rings, and complex functional phenylhydrazones.
• Pharmaceutical Intermediates: Works as a key active reagent for constructing advanced small-molecule APIs, active therapeutic candidates, and complex drug-like chemical structures.
• Acylsulfonamide Preparation: Extensively employed in structural synthetic configurations for creating targeted medicinal acylsulfonamides and therapeutic acylsulfamides.
• Specialty Compounds: Actively involved in building complex polycyclic architectural molecules, including high-value targets like 9-bromo-2-ethenyl-7,12-dihydroindolo[3,2-d]benzazepin-6(5H)-one.
• Enzyme Inhibition Studies: Applied directly in biochemistry and life science discovery programs as a functional tyrosinase inhibitor model to investigate pigmentation and enzymatic catalytic pathways.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.