What is Parecoxib Sodium CAS 198470-85-8?
Parecoxib Sodium CAS 198470-85-8 is the sodium salt form of the parenteral prodrug parecoxib, which undergoes enzymatic conversion to the active COX-2 inhibitor valdecoxib in vivo. As a selective anti-inflammatory and analgesic agent, it provides a water-soluble, injectable form suitable for biochemical, pharmacological, and preclinical research into pain, inflammation, and cyclooxygenase-2–mediated mechanisms.
Specification
| Item |
Value |
| Appearance |
White to off-white powder |
| Melting Point |
273-275 °C |
| Storage Conditions |
Store in an inert atmosphere at 2-8 °C |
Feature
- Prodrug of a Selective COX–2 Inhibitor – Parecoxib Sodium CAS 198470-85-8 is a water-soluble sodium salt form of the prodrug parecoxib that is enzymatically converted to valdecoxib, a selective COX-2 inhibitor with anti-inflammatory and analgesic activity.
- Anti–Inflammatory & Analgesic Mechanisms – Upon conversion to the active metabolite, this compound reduces prostaglandin synthesis by selectively inhibiting COX-2, making it valuable in studies of inflammation, pain, and perioperative analgesia.
- Water–Soluble for Research Applications – The sodium salt’s solubility in aqueous buffers and organic solvents supports its use in formulation research, biochemical assays, and analytical testing.
- Defined Physical Profile – Supplied as a stable white to off-white solid powder with reproducible physicochemical properties, facilitating reliable handling in laboratory environments.
Application
- Inflammation and Pain Research – Used in in vitro and preclinical pharmacology studies focused on understanding anti-inflammatory pathways, COX-2 inhibition, and analgesic effects of prodrug compounds.
- Pharmaceutical R&D & Drug Screening – Utilized as a research intermediate or screening compound in the evaluation of novel NSAIDs, prodrugs, and related therapeutic candidates.
- Biochemical Studies – Suitable for mechanistic studies of enzyme interaction, cyclooxygenase signaling, and metabolic conversion to active NSAID forms.
- Analytical Reference Standard – Applied as a standard in analytical laboratories for calibration, method development, and quality control in assays such as HPLC and LC-MS.
Packaging
Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.
