L-Epicatechin CAS 490-46-0

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L-Epicatechin CAS 490-46-0

CAS: 490-46-0
Molecular Formula: C15H14O6
Molecular Weight: 290.27
EINECS: 207-710-1
HS Code: 29329990

Synonyms: 3,3′,4′,5,7-PENTAHYDROXY-FLAVANE;3,3′,4′,5,7-PENTAHYROXYFLAVONE;3,3′,4′,5,7-PENTAHYDROXYFLAVAN;(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL;(-)-epicatecho;(-)-epicatechol;EPICATECHIN, (-)-;EPICATECHIN, (+)-

What is L-Epicatechin CAS 490-46-0?

L-Epicatechin CAS 490-46-0, also known as (-)-epicatechin or (2R,3R)-epicatechin, is a naturally occurring polyketide-derived flavonoid and flavanol found abundantly in green tea, cocoa beans, chocolate, grape seeds, and various plant barks. It typically appears as a white to light yellow crystalline powder or solid and is hygroscopic in nature.

Recognized for its potent antioxidant capacity and diverse biological activities, L-Epicatechin plays a significant role in promoting cardiovascular health, scavenging free radicals, mitigating oxidative stress, and supporting metabolic and muscle function.

Specifications

Property Value
Appearance White to light yellow crystalline powder / solid
Melting Point 240 °C (dec.) (lit.)
Boiling Point 629.2 °C
Solubility Insoluble in water and ethanol; soluble in DMSO
Storage Conditions Store at -20 °C in a tightly sealed, moisture-protected container

Features

  • Stereospecific Flavanol Structure: Features a 2R,3R-configuration characterized by a dihydroxy-substituted phenyl ring connected to an oxygenated heterocycle.
  • Potent Antioxidant Activity: Efficiently scavenges free radicals (such as DPPH) and outperforms standard vitamins like ascorbate and tocopherol in specific lipid peroxidation assays.
  • Cardiovascular & Nitric Oxide Support: Enhances nitric oxide levels in human endothelial cells, promoting vascular health and circulation.
  • Enzyme Inhibition: Demonstrates targeted inhibitory activity against cyclooxygenase-1 (COX-1) and helps modulate inflammatory and apoptotic pathways.

Applications

  • Nutraceutical & Dietary Supplements: Widely incorporated into health supplements designed to support cardiovascular wellness, muscle performance, and antioxidant defense.
  • Cosmetic Industry: Utilized as a skin-conditioning agent, antioxidant, astringent, and skin-protecting additive in anti-aging and personal care formulations.
  • Pharmaceutical Research: Studied for its antineoplastic properties, apoptosis induction in cancer cells, and potential in mitigating renal inflammation.
  • Food & Beverage Industry: Naturally present or added as a functional bio-active component in cocoa derivatives, green tea extracts, and functional foods.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.

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