2-Methyl-5-nitroaniline CAS 99-55-8
2-Methyl-5-nitroaniline, also known as 5-nitro-o-toluidine, is an intermediate compound in the synthesis of a wide range of azo dyes and
3-Chloroaniline Hydrochloride CAS 141-85-5
3-Chloroaniline Hydrochloride (CAS 141-85-5) is the water-soluble hydrochloride salt of meta-chloroaniline, a chlorinated aromatic amine widely employed as a reactive intermediate in the synthesis of dyes, pharmaceuticals, and pesticides.
3-Chloroaniline Hydrochloride CAS 141-85-5
- CAS: 141-85-5
- Molecular Formula: C6H7Cl2N
- Molecular Weight: 164.03
- EINECS: 205-506-7
- HS Code: 2921.42.9000
- Synonyms: meta-chloroanilinehydrochloride; Naphtoelan Fast Orange GC Base; Naphtoelan Fast Orange GC Salt; naphtoelanfastorangegcbase; Natasol Fast Orange GC Salt; Orange Base Ciba IV; Orange Base Irga IV; Orange Base NGC
What is 3-Chloroaniline Hydrochloride CAS 141-85-5?
3-Chloroaniline Hydrochloride (C₆H₇Cl₂N) CAS 141-85-5 is the protonated, crystalline form of 3-chloroaniline, enhancing solubility and stability for use in aqueous reactions (e.g., diazotization). Key to synthesizing azo dyes and pharmaceuticals (antipsychotics, diuretics), it also drives environmental research via microbial degradation studies (Comamonas testosteroni) for pollutant cleanup. It balances industrial innovation with ecological challenges.
Specifications
| Property | Value |
|---|---|
| Melting point | 222°C (dec.) |
| Color | White to Gray to Brown |
| Form | powder to crystal |
Features
- Physical Properties: White to off-white crystalline powder with high water solubility (up to 6.8 g/L at 20°C), melting point around 250-260°C (decomposes), and low volatility, making it suitable for stable storage in dry conditions without special refrigeration.
- Chemical Reactivity: The protonated amino group (-NH₃⁺) increases polarity and facilitates reactions like coupling or substitution, while the meta-chlorine provides electron-withdrawing effects for selective ortho/para directing; stable in neutral media but decomposes under strong heating or basic conditions.
- Purity and Availability: Commercially available at ≥97-99% purity (by titration or HPLC), often as a fine powder for lab use, with consistent identifiers like InChIKey PNPCRKVUWYDDST-UHFFFAOYSA-N (for base) across suppliers.
- Safety Profile: Acute toxicity via oral/inhalation/skin routes (LD50 ~1-2 g/kg oral in rats); causes severe eye/skin irritation, potential methemoglobinemia, and organ damage (liver/kidney); classified as harmful (H302+H312+H332) and irritant (H315+H318), requiring PPE, ventilation, and inert storage to avoid oxidation or moisture absorption.
Applications
- Dye and Pigment Synthesis: Primary diazo component for azoic and acid dyes like Fast Orange GC Salt, used in printing and dyeing cotton, viscose, and wool fabrics for fast, brilliant orange-red hues in textiles and leather.
- Pharmaceutical Intermediates: Key precursor for drugs including antipsychotics (chlorpromazine hydrochloride), antihypertensives (hydrochlorothiazide), and antimalarials (chloroquine phosphate), aiding in heterocyclic ring formations.
- Pesticides and Agrochemicals: Building block for herbicides like chloraniline and insecticides, enhancing crop protection formulations through its reactivity in amide or imine linkages.
- Research and Bioremediation: Employed in proteomics for protein labeling and microbial studies on aromatic degradation, helping develop strategies to clean up industrial effluents contaminated with chloroanilines.
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Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.
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