{"id":2053,"date":"2026-05-19T09:12:27","date_gmt":"2026-05-19T01:12:27","guid":{"rendered":"https:\/\/www.mikemchem.com\/?post_type=product&p=2053"},"modified":"2026-05-19T09:16:56","modified_gmt":"2026-05-19T01:16:56","slug":"5-chloro-2-methoxyaniline-cas-95-03-4","status":"publish","type":"product","link":"https:\/\/mikemchem.com\/ru\/product\/5-chloro-2-methoxyaniline-cas-95-03-4\/","title":{"rendered":"5-\u0425\u043b\u043e\u0440-2-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0430\u043d\u0438\u043b\u0438\u043d CAS 95-03-4"},"content":{"rendered":"

What is 5-Chloro-2-methoxyaniline CAS 95-03-4?<\/h3>\n

5-Chloro-2-methoxyaniline CAS 95-03-4<\/b> has since become a staple in fine chemical manufacturing, typically produced via selective reduction of 4-chloro-2-nitroanisole using hydrazine hydrate with iron trichloride catalysis in methanol or catalytic hydrogenation under high pressure, with purification via steam distillation or recrystallization to support its integration into large-scale industrial pipelines for dyes, pharmaceuticals, and agrochemicals while adhering to modern sustainability standards in effluent management.<\/p>\n

Specification<\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n
Item<\/td>\nValue<\/td>\n<\/tr>\n
Melting Point<\/td>\n81-83 \u00b0C(lit.)<\/td>\n<\/tr>\n
Boiling Point<\/td>\n135 \u00b0C (5.85078 mmHg)<\/td>\n<\/tr>\n
Density<\/td>\n1.1760 (rough estimate)<\/td>\n<\/tr>\n
pka<\/td>\n3.48\u00b10.10(Predicted)<\/td>\n<\/tr>\n
Fp<\/td>\n136 \u00b0C<\/td>\n<\/tr>\n
Color<\/td>\nPale Grey to Light Grey<\/td>\n<\/tr>\n
Form<\/td>\nSolid<\/td>\n<\/tr>\n
Solubility<\/td>\nChloroform (Slightly), DMSO (Slightly)<\/td>\n<\/tr>\n
Storage Temp.<\/td>\nAmber Vial, -20\u00b0C Freezer, Under inert atmosphere<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Feature<\/h3>\n
    \n
  • Standardized Classification<\/b>: Designated as C.I. Azoic Diazo Component 10 (base) under color index 37120, enabling its standardized use in azo coupling workflows for consistent red shade development across global textile dyeing protocols.<\/li>\n
  • Extensive Synonyms<\/b>: Known by numerous trade and synonyms such as Tulabase Fast Red R, 2-Amino-4-chloroanisole, 5-Chloro-o-anisidine, 4-Chloro-2-aminoanisole, and p-Chloro-o-aminoanisole HCl, reflecting its broad commercial availability and adaptability in multi-vendor supply chains for custom formulations.<\/li>\n
  • Diazotizable Base<\/b>: Serves as a diazotizable base in azoic systems, where its amino group is converted to a stable diazonium salt via nitrous acid treatment, facilitating efficient coupling with naphthol or acetoacetanilide partners to form insoluble pigments without requiring specialized on-site equipment.<\/li>\n
  • Derivatization Support<\/b>: Supports derivatization into hydrochloride salts or isocyanates like 5-chloro-2,4-dimethoxyphenyl isocyanate, extending its role in multi-step syntheses for heterocyclic assemblies through nucleophilic substitutions or amidation reactions.<\/li>\n
  • Hydrogenation Compatibility<\/b>: Compatible with high-pressure hydrogenation techniques using catalysts for dehalogenation or selective reductions, allowing scalable production from precursors like 2,5-dichloronitrobenzene via methoxylation, as detailed in patent processes yielding up to 98% purity.<\/li>\n
  • Regulatory Integration<\/b>: Integrated into regulatory inventories like EINECS 202-385-2 and TSCA, with MDL number MFCD00007777 for cheminformatic tracking, aiding in computational design of dye variants or drug scaffolds while ensuring compliance in export-oriented manufacturing.<\/li>\n<\/ul>\n

    Application<\/h3>\n
      \n
    • Azo Dye and Pigment Manufacturing<\/b>: Primarily employed as a diazo base for producing fast red azoic dyes like Solvent Violet 2 and chromate-complexed azo salts such as disodium hydrogen bis[5-[(5-chloro-2-hydroxyphenyl)azo]-6-hydroxynaphthalene-2-sulphonato(3-)]chromate(3-), applied in cotton printing, viscose dyeing, and silk\/nylon coloration to achieve vibrant scarlet hues with high wash and light fastness.<\/li>\n
    • Textile Coloration Processes<\/b>: Utilized in continuous padding and jigger dyeing of cellulosic fibers like cotton and linen, as well as blended synthetics, where its diazotized form couples on-fiber with developer components to enable discharge printing techniques for apparel, upholstery, and decorative fabrics with minimal bleeding.<\/li>\n
    • Pharmaceutical Synthesis<\/b>: Acts as a key intermediate in constructing appetite-modulating molecules and nitrogen-heterocyclic drugs, including chlorzoxazone analogs for muscle relaxants, through nitro-equivalent reductions followed by amide couplings or cyclizations to form pharmacophores targeting metabolic pathways.<\/li>\n
    • Agrochemical Development<\/b>: Incorporated into the production of herbicides and fungicides, leveraging its halogenated aniline structure for aryl substitutions in pyrazole or triazole scaffolds that enhance pest selectivity and environmental persistence in crop protection formulations.<\/li>\n
    • Polymer and Industrial Chemical Production<\/b>: Employed in synthesizing specialty polymers and additives, such as through reactions with methylenesuccinic acid to yield pyrrolidine derivatives for flame retardants or UV stabilizers, supporting applications in plastic masterbatches and coatings for automotive and packaging industries.<\/li>\n
    • Organic Research and Fine Chemicals<\/b>: Serves as a reagent in laboratory-scale explorations of bioactive amines, including the preparation of N-(5-chloro-2-methoxyphenyl)-3-oxobutanamide for potential enzyme inhibitors, advancing studies in medicinal chemistry and materials science for sensor technologies or fluorescent tags.<\/li>\n<\/ul>\n

      Packaging<\/h3>\n

      Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15\u201325 kg PP\/PE bags for powder products, all customizable to meet your specific needs.<\/p>\n","protected":false},"excerpt":{"rendered":"

      CAS: 95-03-4
      \n\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u0444\u043e\u0440\u043c\u0443\u043b\u0430: C7H8ClNO
      \n\u041c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u0430\u044f \u043c\u0430\u0441\u0441\u0430: 157,6
      \nEINECS: 202-385-2
      \n\u041a\u043e\u0434 HS: 29222990<\/p>\n

      \u0421\u0438\u043d\u043e\u043d\u0438\u043c\u044b: 2-\u0430\u043c\u0438\u043d\u043e-4-\u0445\u043b\u043e\u0440\u0430\u043d\u0438\u0437\u043e\u043b; 5-\u0445\u043b\u043e\u0440-2-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0431\u0435\u043d\u0437\u0435\u043d\u0430\u043c\u0438\u043d; C.I.37120 (\u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0435); C.I.AzoicDiazoComponent10 (\u043e\u0441\u043d\u043e\u0432\u0430\u043d\u0438\u0435); TulabaseFastRedR; 5Chemicalbook \u2014 \u0445\u043b\u043e\u0440-\u043e-\u0430\u043d\u0438\u0437\u0438\u0434\u0438\u043d; 4-\u0445\u043b\u043e\u0440-2-\u0430\u043c\u0438\u043d\u043e\u0430\u043d\u0438\u0437\u043e\u043b; 2-\u0430\u043c\u0438\u043d\u043e-4-\u0445\u043b\u043e\u0440\u0430\u043d\u0438\u0437\u043e\u043b; 5-\u0445\u043b\u043e\u0440-\u043e-\u0430\u043d\u0438\u0437\u0438\u0434\u0438\u043d, 98%; 5-\u0445\u043b\u043e\u0440-2-\u043c\u0435\u0442\u043e\u043a\u0441\u0438\u0431\u0435\u043d\u0437\u043e\u043b\u0430\u043c\u0438\u043d<\/p>","protected":false},"featured_media":2054,"template":"","meta":[],"product_brand":[],"product_cat":[18],"product_tag":[],"class_list":["post-2053","product","type-product","status-publish","has-post-thumbnail","product_cat-pigments-and-dyes","first","instock","shipping-taxable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/product\/2053","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/media\/2054"}],"wp:attachment":[{"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/media?parent=2053"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/product_brand?post=2053"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/product_cat?post=2053"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/mikemchem.com\/ru\/wp-json\/wp\/v2\/product_tag?post=2053"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}