What is Acetamidine hydrochloride CAS 124-42-5?
Acetamidine hydrochloride CAS 124-42-5, also known as ethanimidamide hydrochloride, is an amidine-based compound typically obtained as a hydrochloride salt and extensively applied as a nitrogen-containing building block in organic synthesis, especially for the preparation of heterocycles, pharmaceuticals, and bioactive molecules.
Specification
| Item |
Value |
| Appearance |
White to cream Crystalline Powder, Crystals and/or Chunks |
| Melting Point |
165-170 °C(lit.) |
| Boiling Point |
129.78°C (rough estimate) |
| Density |
1.0596 (rough estimate) |
| pka |
pK1: 1.60(+1) (25°C) |
| Storage Temp |
Inert atmosphere, Room Temperature |
Feature
- Amidine Type: Belongs to the amidine class, serving as a nitrogen-rich synthetic intermediate.
- Reactive Reagent: Acts as an effective ammonia-equivalent source in various substitution and coupling reactions.
- Synthesis Versatility: Enables formation of diverse nitrogen-containing heterocycles and derivatives.
- Pharma Relevance: Widely used in the development of pharmaceutical intermediates and bioactive compounds.
- Stable Salt Form: Commonly handled as a hydrochloride salt, facilitating storage and industrial use.
Application
- Vitamin Synthesis: Key raw material in the production of vitamin B1 (thiamine).
- Antibiotic Intermediate: Used in synthesizing imidazole, pyrimidine, and triazine-based antimicrobial compounds.
- Heterocycle Building: Applied in the preparation of nitrogen-containing heterocyclic compounds.
- Organic Reagent: Functions as a reagent in nucleophilic substitution and catalytic amination reactions.
- Pharma Intermediate: Serves as a precursor in active pharmaceutical ingredient (API) synthesis.
Packaging
Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.