Pyridine-3-sulfonyl Chloride CAS 16133-25-8

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Pyridine-3-sulfonyl Chloride CAS 16133-25-8

CAS: 16133-25-8
Molecular Formula: C5H4ClNO2S
Molecular Weight: 177.61
EINECS: 688-270-1
HS Code: 2933399990

Synonyms: 3-CHLOROSULFONYL-PYRIDINIUM,CHLORIDE; 3-PYRIDINESULFONYLCHLORIDE,HCL; Piperidine-3-sulfonylchloride; Vonoprazanintermediate; pyridine-3-sulfonylchloride(SALTDATA:0.8HCl0.3H2O); Vonoprazan-8; Vonoprazan-029; VonoprazanImpurity50

What is Pyridine-3-sulfonyl Chloride CAS 16133-25-8?

Pyridine-3-sulfonyl chloride CAS 16133-25-8 is a functionalized pyridine derivative widely employed as a sulfonylating reagent in organic synthesis, particularly valued for introducing sulfonyl groups into nitrogen-containing heterocycles and other bioactive frameworks, making it a key intermediate in the development of advanced pharmaceutical compounds and specialty chemicals.

Specifications

Property Value
Appearance Colourless to light yellow liquid
Melting Point 144 °C
Boiling Point 284℃
Density 1.488
pka -1.77±0.11(Predicted)
Fp 126℃
Storage Conditions Under inert gas (nitrogen or Argon) at 2-8°C

Features

  • High Reactivity: Efficient sulfonylation agent enabling rapid formation of sulfonamide and related derivatives.
  • Selective Functionalization: Provides targeted modification on pyridine-based systems, useful in heterocyclic chemistry.
  • Intermediate Role: Acts as a versatile building block in multi-step synthesis of complex molecules.
  • Process Compatibility: Suitable for controlled synthetic routes in pharmaceutical and fine chemical production.

Applications

  • Pharma Intermediate: Widely used in the synthesis of drug molecules, including intermediates for acid-suppressing agents such as vonoprazan.
  • Sulfonamide Synthesis: Serves as a key reagent for preparing biologically active sulfonamide derivatives.
  • Heterocycle Modification: Enables structural diversification of pyridine and related heterocyclic compounds.
  • Bioactive Compounds: Applied in the development of compounds with antiproliferative or medicinal activity.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.

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