What is Pyridine-3-sulfonyl Chloride CAS 16133-25-8?
Pyridine-3-sulfonyl chloride CAS 16133-25-8 is a functionalized pyridine derivative widely employed as a sulfonylating reagent in organic synthesis, particularly valued for introducing sulfonyl groups into nitrogen-containing heterocycles and other bioactive frameworks, making it a key intermediate in the development of advanced pharmaceutical compounds and specialty chemicals.
Specifications
| Property |
Value |
| Appearance |
Colourless to light yellow liquid |
| Melting Point |
144 °C |
| Boiling Point |
284℃ |
| Density |
1.488 |
| pka |
-1.77±0.11(Predicted) |
| Fp |
126℃ |
| Storage Conditions |
Under inert gas (nitrogen or Argon) at 2-8°C |
Features
- High Reactivity: Efficient sulfonylation agent enabling rapid formation of sulfonamide and related derivatives.
- Selective Functionalization: Provides targeted modification on pyridine-based systems, useful in heterocyclic chemistry.
- Intermediate Role: Acts as a versatile building block in multi-step synthesis of complex molecules.
- Process Compatibility: Suitable for controlled synthetic routes in pharmaceutical and fine chemical production.
Applications
- Pharma Intermediate: Widely used in the synthesis of drug molecules, including intermediates for acid-suppressing agents such as vonoprazan.
- Sulfonamide Synthesis: Serves as a key reagent for preparing biologically active sulfonamide derivatives.
- Heterocycle Modification: Enables structural diversification of pyridine and related heterocyclic compounds.
- Bioactive Compounds: Applied in the development of compounds with antiproliferative or medicinal activity.
Packaging
Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.