What is 3-Aminobenzoylmethylamide CAS 25900-61-2?
3-Aminobenzoylmethylamide CAS 25900-61-2, also widely known as 3-amino-N-methylbenzamide or 3-(methylcarbamoyl)aniline, is an aromatic organic compound belonging to the benzamide derivative family. Featuring a benzene core functionalized with both a reactive meta-amino group and a stable secondary methylamide group, it serves as a highly specialized building block. It is primarily supplied at high purity for use as an intermediate in advanced organic synthesis, medicinal chemistry drug discovery platforms, and industrial chemical research.
Specifications
| Property |
Value |
| Appearance |
White to light yellow to light red powder to crystalline |
| Melting Point |
119 °C |
| Boiling Point |
346.7 ± 25.0 °C (Predicted) |
| Density |
1.137 ± 0.06 g/cm³ (Predicted) |
| pka |
15.19 ± 0.46 (Predicted) |
| Storage Conditions |
Store in a dark place, sealed in a dry environment at room temperature. Keep container tightly closed in a cool, well-ventilated storage area away from moisture, heat, open flames, and strong oxidizing agents. |
Features
- Bifunctional Benzamide Core: Combines a nucleophilic meta-positioned primary amine with an N-methylamide tail, offering excellent structural properties for regioselective synthesis and molecular engineering.
- High Synthetic Purity: Formulated to superior industrial specifications (≥98% by HPLC) to ensure highly predictable performance, minimal side reactions, and clean crystallization phases.
- Stable Solid Configuration: Delivered as a robust, uniform crystalline powder or solid matrix, providing easier physical handling, long-term storage stability, and precise plant batching compared to liquid amines.
- Favorable Scaffold Reactivity: The amino handle easily undergoes standard acylation, alkylation, diazotization, or transition-metal catalyzed cross-coupling without affecting the secondary amide framework.
Applications
- Organic Synthesis: Extensively utilized as an organic building block and intermediate to prepare highly substituted benzamide derivatives, specialized nitrogen heterocycles, and custom coupling products.
- Medicinal Chemistry: Heavily applied in drug discovery pipelines and academic research to build or modify pharmacologically relevant small-molecule scaffolds, enzyme inhibitors, and complex active pharmaceutical ingredients (APIs).
- Laboratory Research: Deployed as a reliable analytical standard, chemical probe, or diagnostic reagent in laboratory R&D, process optimization trials, and custom validation methodologies.
- Fine Chemical & Dye Production: Serves as an upstream structural material for constructing high-performance organic additives, photo-stabilizers, and targeted industrial functional molecules.
Packaging
Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.