3,5-Dibromopyridine CAS 625-92-3

What is 3,5-Dibromopyridine CAS 625-92-3?

3,5-Dibromopyridine CAS 625-92-3 is integral to modern synthetic chemistry, enabling the precise modification of pyridine rings through sequential halogen displacements and is manufactured via bromination of pyridine precursors, with widespread availability from international suppliers in bulk quantities to support everything from exploratory research to industrial-scale operations.

Specification

Feature

• Dibromo selective coupling: Offers dual bromine atoms at meta positions, allowing for selective mono- or di-substitution in a wide array of palladium-catalyzed cross-coupling reactions like Suzuki, Stille, and Negishi couplings to introduce diverse aryl, alkyl, or heteroaryl groups.
• Organometallic compatible: Exhibits strong compatibility with organometallic reagents, such as lithium diisopropylamide (LDA) for directed lithiation at the 4-position, facilitating the introduction of electrophiles to generate unsymmetrically substituted pyridines in high yields.
• Multi-step cascade synthesis: Demonstrates versatility in multi-step synthetic cascades, including chemoselective reactions with azides or isocyanates, making it ideal for building elaborate molecular architectures without interference from steric hindrance.
• High purity bulk supply: Commercially accessible in purities exceeding 98% from multiple vendors, with scalable production options that streamline integration into automated synthesis workflows and reduce development timelines for new compounds.

Application

• Neurology drug intermediate: Pharmaceutical intermediate, particularly in the synthesis of nicotinic acetylcholine receptor agonists like TC-2559 for treating neurological disorders such as Alzheimer’s and Parkinson’s diseases, as well as other active pharmaceutical ingredients (APIs) through targeted derivatization.
• Anti-inflammatory raw material: Organic synthesis for creating bioactive pyridine derivatives, including 3-acetamido-5-ethoxypyridine via ethoxylation and amination sequences, which serve as precursors for anti-inflammatory and antimicrobial agents.
• Catalyst & sensor material: Materials science, employed in the preparation of metal coordination complexes, such as Hg(II) ligands with halogenated pyridines, for applications in catalysis and sensor development.
• Semiconductor photoresist: Electronic chemicals, acting as a high-purity building block in photoresist formulations for semiconductor manufacturing, enhancing resolution and performance in advanced lithography processes.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.