4-Fluorophenylhydrazine hydrochloride CAS 823-85-8

What is 4-Fluorophenylhydrazine hydrochloride CAS 823-85-8?

4-Fluorophenylhydrazine hydrochloride CAS 823-85-8 primarily serves as a nucleophilic hydrazine reagent in condensation and cyclization reactions to produce fluorinated heterocycles like indoles, pyrazoles, and other nitrogen-containing structures, with key roles in medicinal chemistry and agrochemical development.

Specifications

Features

• Para-Fluoro Substitution: Introduces a critical fluorine atom at the para position, significantly altering metabolic stability, lipophilicity, and bioactivity profiles in final target structures.
• High Purity Grades: Available at refined analytical and industrial grades (≥97% to ≥99% by HPLC/NMR) to ensure predictable reaction conversion and minimal side product development.
• Reactive Hydrazine: Features a highly nucleophilic hydrazine group that readily drives hydrazone formation, condensation, and rapid heterocyclic ring cyclizations.
• Powder Form: Supplied as a stable, uniform powder (ranging from white to brownish/yellow/orange variants), allowing for precise weighing and bulk mixing.
• Stable Storage: The hydrochloride salt form offers superior shelf-life stability and resistance to direct atmospheric degradation compared to its unstable free-base analogue.

Applications

• Pharmaceutical Intermediate: Widely utilized as an indispensable upstream core building block for synthesizing tryptamine-based receptor agonists, anti-migraine medications (such as triptan class drugs), and cluster headache treatments.
• Indole Synthesis: Extensively used in Fischer Indole Synthesis pathways to cleanly construct specialized fluorinated indoles, such as 5-fluoro-2-methylindole and related derivatives.
• Heterocyclic Preparation: Serves as a versatile raw material in building highly functionalized pyrazoles, indazoles, and multi-nitrogen pharmaceutical ring frameworks.
• Agrochemical Synthesis: Contributes heavily to the modern structural development and custom manufacturing of fluorinated crop-protection agents, fungicides, and targeted herbicides.
• Organic Building Block: Applied broadly in medicinal chemistry platforms for creating novel small-molecule kinase inhibitors, targeted anti-cancer agents, and bioactive probes.
• Analytical Reagent: Employed selectively in laboratory diagnostics as a functional derivatization reagent for the chromatographic tracking and separation of sugars, free aldehydes, and structural carbonyl compounds.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.