Indometacin CAS 53-86-1

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Indometacin CAS 53-86-1

CAS: 53-86-1
Molecular Formula: C19H16ClNO4
Molecular Weight: 357.79
EINECS: 200-186-5

Synonyms: indomethacin crystalline; indomethacin methanol solution; indomethacin usp; AURORA KA-6542; INDOMETACIN; LABOTEST-BB LT00244830; INDOMETHACIN BP99; N-(4-Chlorobenzoyl)-4-Methoxyphenyl-Hydrazine

What is Indometacin CAS 53-86-1?

Indometacin CAS 53-86-1 is an orally active non-steroidal anti-inflammatory research compound with potent inhibition of cyclooxygenase (COX) enzymes, making it valuable in studies of inflammation pathways, prostaglandin biosynthesis, and related pharmacological models. It is supplied as a white to off-white crystalline powder and is commonly used as a reference standard or intermediate in pharmaceutical and biochemical research.

Specification

Item Value
Appearance White to off-white powder to light yellow/light orange powder
Melting Point 158–162 °C
Boiling Point 499.4±45.0 °C (predicted)
Density 1.2135 g/cm³ (estimate)
Storage Conditions Store at room temperature (cool, dry place)

Feature

  • Potent Anti-Inflammatory Agent: Exhibits strong inhibitory effects on cyclooxygenase enzymes, making it a key compound for studying prostaglandin-mediated inflammation pathways in vitro and in preclinical models.
  • Broad Research Applicability: Widely used as a research reference standard in pharmacology, biochemistry, and analytical method development.
  • Crystalline Solid Form: Stable, well-defined solid suitable for formulation research and analytical calibration studies.
  • Organic Solvent Solubility: Compatible with common organic solvents for solution preparation in laboratory protocols.

Application

  • Pharmacological Research: Utilized in studies examining cyclooxygenase inhibition, prostaglandin biosynthesis mechanisms, and inflammatory response modulation.
  • NSAID Mechanism Studies: Used as a model compound in research into non-steroidal anti-inflammatory drug (NSAID) activity and comparative efficacy profiling.
  • Analytical Standard: Employed as a reference or calibration standard in HPLC, LC-MS, and other analytical methods in pharmaceutical quality control and research settings.
  • Intermediate in Synthesis: Applied as an intermediate in medicinal chemistry and synthetic studies of related anti-inflammatory analogs.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.

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