L-Menthyl acetate CAS 2623-23-6

What is L-Menthyl acetate CAS 2623-23-6?

L-Menthyl acetate CAS 2623-23-6 is a FEMA (2668) and JECFA (431) approved edible spice, existing as a colourless liquid with characteristic mentholic minty herbal tea fruity woody floral earthy odor. As a naturally occurring p-menthane monoterpenoid, it is found in peppermint oils. Synthesized by acetylation of L-menthol (with acetic anhydride) or direct esterification of racemic menthol with acetic acid under azeotropic conditions, it exhibits low toxicity (LD50 orally in Rabbit >5000 mg/kg) and acts as an efficient skin penetration enhancer for drugs with varying lipophilicities. With stable physical and chemical properties under normal temperature sealed storage, it is supplied in 97.80%、98%(Min,HPLC)、99% and 99%+ HPLC high purity grades, widely applied in food, daily chemical, pharmaceutical and chiral synthesis fields.

Feature

1. Dual Aroma Characteristics – With fresh mentholic minty notes and complementary fruity, woody, floral nuances, it is the core raw material for formulating natural peppermint and fruit-floral composite flavors.
2. Skin Penetration Enhancement – Effectively enhances the skin permeation of drugs with differing lipophilicities (such as ALA, 5-FU, ISDN, lidocaine), improving transdermal drug delivery efficiency.
3. Chiral Building Block Property – As a natural (1R)-configured chiral ester, it serves as a key intermediate for the synthesis of chiral drugs, ligands and fine chemicals.
4. Approved Edible Spice Grade – Certified by FEMA and JECFA, compliant with food safety standards, suitable for direct use in food and beverage flavor formulation.
5. Natural Occurrence in Essential Oils – Found in peppermint oils, with good natural flavor compatibility and authenticity, ideal for reconstituted peppermint oil preparation.
6. Low Toxicity and Safety – Low toxicity by ingestion and skin contact, meeting the safety requirements of food, cosmetic and pharmaceutical applications.
7. Stable Storage Property – Stable under normal storage conditions, not easy to decompose, and can be stored for a long time when sealed.
8. Multi-industry Adaptability – Integrates flavoring, penetration enhancement and chiral synthesis functions, with diverse application scenarios in multiple fields.

Application

1. Food Flavor Formulation – Used to blend peppermint, spearmint, raspberry, peach and other fruit-floral flavors, applied in flavoring of candies, chewing gum, beverages, baked food and oral care products (toothpaste, mouthwash), enhancing the fresh minty and fruity notes.
2. Daily Chemical Perfuming – Modulates rose, lily of the valley and other floral fragrances, and is used in cosmetics, toilet water, soap and air fresheners; also applied in citrus and oriental fragrances to add fresh mentholic layers.
3. Pharmaceutical Field – Serves as a skin penetration enhancer in transdermal drug delivery systems, improving the absorption efficiency of 5-aminolevulinic acid (ALA), 5-fluorouracil (5-FU) and other drugs; acts as a pharmaceutical raw material and chiral intermediate for drug synthesis.
4. Cosmetic Production – Added to skin care products (lotions, creams, essences) as a penetration enhancer, promoting the absorption of active ingredients; used as a fragrance ingredient to provide fresh minty aroma and improve product sensory experience.
5. Organic Synthesis – As a chiral building block, it is used in the synthesis of chiral compounds, pharmaceutical intermediates and natural products; serves as a reference substance in chiral separation and analysis.
6. Essential Oil Reconstitution – The core component of reconstituted peppermint oil, used in the production of natural-flavor essential oils for food, daily chemical and pharmaceutical industries.
7. Tobacco Flavoring – Added to tobacco products to enrich the smoke flavor with fresh minty notes, reducing irritation and improving the sensory comfort of cigarettes.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.