What is LDAO CAS 1643-20-5?
LDAO CAS 1643-20-5, also known as Lauryldimethylamine oxide (or dodecyldimethylamine oxide / DDAO), is a zwitterionic amine oxide surfactant containing a hydrophobic twelve-carbon alkyl tail linked to a highly polar, hydrophilic amine oxide head group. Depending on the pH of the system, it exhibits non-ionic properties under neutral and alkaline conditions and cationic characteristics in acidic environments. Widely valued for its unique amphiphilic nature, LDAO is a premier detergent utilized extensively in membrane protein structural biology, as well as an excellent foam stabilizer and viscosity modifier in commercial personal care and cleaning formulations.
Specifications
| Item |
Value |
| Appearance |
White to off-white crystalline solid |
| Melting Point |
132-133 °C(lit.) |
| Boiling Point |
371.32°C (rough estimate) |
| Density |
0.996 g/mL at 20 °C |
| Fp |
113°C |
| pka |
4.79±0.40(Predicted) |
| Form |
A crystalline solid |
| pH |
7.0-9.0 (25°C, 0.1M in H2O) |
| Storage Temp. |
-20°C |
Features
- Amphiphilic Surfactant Behavior: Forms highly uniform micelles at low critical micelle concentration (CMC) values, allowing it to efficiently partition and interact with both hydrophobic matrices and polar aqueous environments.
- Mild, Non-Denaturing Detergent: Possesses a gentle token of action that easily solubilizes fragile membrane-bound proteins and assemblies without disrupting their secondary structures or native enzymatic activities.
- Exceptional Foam & Viscosity Boosting: Acts as an outstanding foam builder and rheology modifier, creating rich, dense, and highly stable creamy lathers in surfactant matrices.
- Broad Formulation Synergy: Blends seamlessly with anionic, non-ionic, and amphoteric surfactants, actively mitigating the skin irritation potential of harsher primary detergents like SLES while enhancing overall antistatic and conditioning performance.
Applications
- Membrane Protein Research & Purification: Extensively utilized by structural biologists and biochemists to extract, solubilize, and stabilize hydrophobic membrane-bound targets, including ion channels, receptors, and respiratory complexes.
- X-ray Crystallography & Protein Analysis: Heavily relied upon in membrane protein crystallization trials, nuclear magnetic resonance (NMR) spectroscopy, and high-molecular-weight protein detection workflows.
- Cosmetics & Personal Care: Formulated into premium shampoos, liquid hand soaps, facial washes, and bubble baths as a dependable conditioning agent, stabilizer, detangler, and viscosity modifier.
- Household & Industrial Cleaning: Incorporated into high-performance liquid dishwashing detergents and hard-surface cleaners where rapid grease emulsification, low residue tracking, and deep wetting are required.
- Mixed-Surfactant Engineering: Applied as a secondary surfactant tool to customize texture profiles, reduce skin-stripping effects, and improve long-term thermal stability in multi-component commercial emulsions.
Packaging
Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.