Lornoxicam CAS 70374-39-9

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Lornoxicam CAS 70374-39-9

CAS: 70374-39-9
Molecular Formula: C13H10ClN3O4S2
Molecular Weight: 371.82
EINECS: 630-354-7

Synonyms: LORNOXICAM; AKOS 93662; 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide; LornoxicaM for injection; 6-Chloro-4-hydroxy-2-Methyl-N-2-pyridinyl-; LornoxicaM API; 6-Chloro-4-hydroxy-2-Methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxaMide; LornoxicaM (Xefo)

What is Lornoxicam CAS 70374-39-9?

Lornoxicam CAS 70374-39-9 is a nonselective non-steroidal anti-inflammatory compound belonging to the oxicam class. It is recognized for its balanced inhibitory effects on cyclooxygenase enzymes (COX-1 and COX-2), leading to reduced prostaglandin synthesis and pronounced relief of inflammation and pain. This profile makes it a valuable research compound and intermediate in pharmaceutical development, especially in studies of inflammatory disease models and analgesic mechanisms.

Specification

Item Value
Appearance Yellow crystalline powder
Melting Point 228–230 °C
Solubility Slightly soluble in water; soluble in organic solvents like DMSO and methanol
Storage Conditions Store at 2–8 °C, protected from light and moisture
Purity ≥98% (HPLC)

Feature

  • Potent COX Inhibition: Effectively inhibits both COX-1 and COX-2 isoforms, providing strong anti-inflammatory and analgesic effects in experimental models.
  • Rapid Onset of Action: Known for its quick absorption and onset of effect, making it valuable for acute pain studies.
  • High Bioavailability: Demonstrates good oral bioavailability, facilitating its use in pharmacokinetic and pharmacodynamic research.
  • Well-Characterized Profile: Extensively studied with a known safety and efficacy profile, serving as a reliable reference compound in NSAID research.
  • Stable Crystalline Form: Provided as a stable yellow powder suitable for accurate weighing and consistent experimental results.

Application

  • Pain Management Research: Used in preclinical studies to evaluate efficacy in treating acute and chronic pain conditions, including post-operative and musculoskeletal pain.
  • Inflammation Studies: Applied in models of inflammatory diseases to investigate mechanisms of action and therapeutic potential.
  • Pharmacological Profiling: Employed in comparative studies of NSAIDs to assess potency, selectivity, and side effect profiles.
  • Analytical Reference Standard: Serves as a high-purity standard for method validation in HPLC and other analytical techniques in quality control laboratories.
  • Biochemical Assays: Utilized in enzymatic assays studying cyclooxygenase activity and prostaglandin synthesis pathways.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.

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