Methoxypolyethylene Glycol Amine CAS 80506-64-5

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Methoxypolyethylene Glycol Amine CAS 80506-64-5

CAS: 80506-64-5
Molecular Formula: C₅H₁₃NO₂ (repeating unit varies by MW)
Molecular Weight: 119.16 (base unit)
EINECS: /
HS Code: 39072090

Synonyms: mPEG‑NH₂; Methoxy PEG amine; Poly(ethylene glycol) methyl ether amine; mPEG‑Amine; PEG‑NH2

What is Methoxypolyethylene Glycol Amine CAS 80506-64-5?

Methoxypolyethylene Glycol Amine (mPEG‑NH₂) CAS 80506-64-5 is a monodisperse or polydisperse polyethylene glycol derivative with a reactive primary amine end group and a terminal methoxy group. It is widely used as a bioconjugation linker, PEGylation reagent, and reactive intermediate for pharmaceuticals, proteins, peptides, and advanced biomaterials.

Specification

Item Value
Appearance White to off‑white granular solid
Melting Point 58–61 °C
Flash Point >110 °C
Molecular Weight Custom: 500, 1000, 2000, 5000, 10000, 20000
Purity ≥95% (HPLC)
Storage Condition 2–8 °C, sealed, dry, away from light

Feature

  • Reactive Amine Group: Reacts smoothly with NHS esters, carboxylic acids, aldehydes, and isocyanates for stable bioconjugation.
  • Excellent Hydrophilicity: Strong water solubility improves bioavailability and dispersion of hydrophobic drugs.
  • Low Immunogenicity: Reduces protein recognition and extends circulation half‑life in vivo.
  • Good Biocompatibility: Non‑toxic, non‑antigenic, widely approved for biomedical use.
  • Flexible MW Range: Available in multiple molecular weights to meet different conjugation requirements.

Application

  • Protein & Peptide PEGylation: Modify antibodies, enzymes, and peptides to improve stability and half‑life.
  • Drug Delivery Systems: Conjugate with small‑molecule drugs for targeted and sustained release.
  • Biomaterial Modification: Functionalize nanoparticles, liposomes, micelles, and surfaces.
  • Gene & Nucleic Acid Delivery: Improve solubility and biocompatibility of DNA/siRNA vectors.
  • Chemical Intermediate: Key building block for graft polymers, hydrogels, and diagnostic probes.

Packaging

Mikem offers flexible packaging options, including 25 kg fiber drums and 15–25 kg PP/PE bags for solid products, all customizable to meet your specific needs.

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