What is Pyrrolidine CAS 123-75-1?
Pyrrolidine CAS 123-75-1 is a saturated heterocyclic organic compound featuring a five-membered ring composed of four carbon atoms and one nitrogen atom. It is a colorless to pale yellow liquid with a penetrating, ammonia-like odor. As a cyclic secondary amine, it behaves chemically similar to other secondary amines, undergoing reactions such as Leuckart-Wallach and Mannich reactions. It is widely used as an essential building block in chemical synthesis and as an intermediate in the pharmaceutical and agricultural industries. Although synthetically produced for industrial use, it is also found naturally in various foods and plants.
Specifications
| Property |
Value |
| Appearance |
Colorless to almost colorless liquid |
| Melting Point |
-63 °C |
| Boiling Point |
87-88 °C (at 760 mmHg) |
| Density |
0.852 g/mL (at 25 °C) |
| Storage Conditions |
Store below +30 °C; protect from light and humid air |
Features
- Reactivity: Functions as a typical secondary amine, making it a versatile reactant for forming enamines and participating in complex oxidative aminations.
- Miscibility: It is infinitely miscible with water and a wide range of conventional organic solvents (such as methanol, acetone, ether, and chloroform), facilitating its use in varied solvent systems.
- Catalytic Applications: Can be utilized directly as a catalyst in organic chemistry, such as in the synthesis of N-sulfinyl aldimines from carbonyl compounds and sulfonamides.
- Precursor Molecule: It is a fundamental building block whose ring structure is a core component in many naturally occurring alkaloids and synthetic pharmaceutical agents.
Applications
- Pharmaceutical Synthesis: Extensively used as a building block and intermediate in the synthesis of a wide range of pharmaceutical compounds, including matrix metalloprotein inhibitors (MMPIs), aminopeptidase N inhibitors (APNIs), and drugs like Ramipril and Alizapride.
- Agrochemical Production: Functions as a critical chemical intermediate in the preparation and synthesis of various pesticides and agricultural chemicals.
- Industrial Chemistry: Employed to prepare rubber accelerators and serves as a fundamental heterocyclic building block in fine chemical synthesis.
- Flavor & Fragrance: Utilized in controlled amounts within the flavor industry due to its occurrence in natural products, providing specific ammoniacal and animalic nuances.
Packaging
Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.