2-Hydroxypropyl-α-cyclodextrin CAS 128446-33-3

What is 2-Hydroxypropyl-α-cyclodextrin CAS 128446-33-3?

2-Hydroxypropyl-α-cyclodextrin CAS 128446-33-3 is a chemically modified α-cyclodextrin produced by introducing hydroxypropyl groups onto the native cyclodextrin structure. This modification significantly improves its solubility in water and enhances its ability to form inclusion complexes with hydrophobic molecules. Due to its smaller cavity size compared to β- and γ-cyclodextrins, it is particularly suitable for encapsulating small molecular compounds, making it valuable in pharmaceutical delivery systems, analytical chemistry, and specialty formulations.

Specifications

Features

• Enhanced Water Solubility: Hydroxypropyl substitution significantly increases solubility compared to native α-cyclodextrin, enabling efficient use in aqueous systems.
• Selective Inclusion Capability (Small Molecules): Smaller cavity size allows selective encapsulation of low-molecular-weight compounds, offering targeted formulation advantages.
• Improved Stability of Active Ingredients: Forms stable inclusion complexes with sensitive compounds such as iodine, enhancing stability and solubility.
• Biocompatibility & Low Toxicity: Suitable for pharmaceutical, cosmetic, and food-related applications due to its favorable safety profile.

Applications

• Pharmaceutical Formulations: Used as a solubilizer and carrier for small-molecule drugs in oral, injectable, and topical formulations.
• Drug Delivery & Gene Systems: Applied in advanced delivery systems, including polymer-based carriers and gene delivery vectors.
• Analytical Chemistry: Utilized as a chiral selector in capillary electrophoresis for enantiomer separation.
• Cosmetics & Functional Formulations: Used as a stabilizer and encapsulating agent in skincare and cosmetic systems.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.