3-Fluorophenylhydrazine hydrochloride CAS 2924-16-5

What is 3-Fluorophenylhydrazine hydrochloride CAS 2924-16-5?

3-Fluorophenylhydrazine hydrochloride CAS 2924-16-5 primarily serves as a reactive hydrazine reagent in the preparation of various substituted pyrazoles, indazoles, and other nitrogen-containing heterocycles relevant to medicinal chemistry and research applications.

Specifications

Features

• Versatile Building Block: Highly useful for constructing complex fluorinated core scaffolds and custom multi-ring aromatic molecules.
• High Purity Options: Commercially available in high-purity processing grades (97–99%) to maintain predictable reaction metrics and simplify downstream purification.
• Reactive Hydrazine: Features an active nucleophilic hydrazine tail that drives efficient condensation, hydrazone formation, and multi-step cyclization reactions.
• Fluorine Substitution: Introduces a strategic meta-fluoro motif onto the benzene ring, altering target molecule lipophilicity, binding affinity, and metabolic stability.
• Stable Powder Form: Supplied as a stable white to light brown crystalline solid, maximizing handling shelf-life and processing ease compared to volatile free bases.

Applications

• Pyrazole Synthesis: Acts as a key foundational reagent for preparing meta-fluorinated pyrazole derivatives, pyrazolinones, and core pyrazole carboxylic acid esters.
• Pharmaceutical Intermediate: Extensively used in medicinal chemistry platforms for discovering and optimizing bioactive small-molecule APIs and drug candidates.
• Heterocyclic Preparation: Frequently employed to construct highly tailored indazoles, fluorinated indoles (via Fischer indole synthesis), and related structural N-heterocycles.
• Organic Building Block: Serves as a versatile fluorinated arylhydrazine component for assembling complex functionalized compounds, liquid crystals, and specialized performance additives.
• Research Reagent: Applied regularly in academic synthetic studies, structure-activity relationship (SAR) tracking, and custom proteomics-related derivatization workflows.
• Agrochemical Use: Contributes to the developmental synthesis and manufacturing of highly potent fluorinated pesticides, fungicides, and crop-protection agents.

Packaging

Mikem offers flexible packaging options, including 25 kg of fiber drums for liquid products and 15–25 kg PP/PE bags for powder products, all customizable to meet your specific needs.